The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.

Top Cast

Tobey MaguireSpider-Man / Peter Parker

Kirsten DunstMary Jane Watson

James FrancoNew Goblin / Harry Osborn

Thomas Haden ChurchSandman / Flint Marko

Topher GraceVenom / Eddie Brock

Bryce Dallas HowardGwen Stacy

Rosemary HarrisMay Parker

J.K. SimmonsJ. Jonah Jameson